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Laser Assisted Hatching

Laser Assisted Hatching

Αssisted Ηatching is a micromanipulative technique, which is used to increase implantation rates by facilitating hatching of the embryos following IVF/ICSI.

In order for an embryo to complete implantation in the endometrium, it must grow until the blastocyst stage and break through the outer membrane known as Zona Pellucida. The Zona Pellucida is a glycoprotein layer, which completely surrounds the oocyte. It is present while the oocyte is developing in the ovary and remains the same shape and size up to the blastocyst stage. The blastocyst may fail to hatch because it become entrapped in an unyielding zona. It has, therefore, been speculated that if a hole is made in the zona, this would aid the hatching process.

Currently, there are three methods of Assisted Harching, the mechanical (Partial Zona Dissection), the chemical (Zona Drilling) and the Laser assisted. Nowadays, is a Laser performed procedure that provides a precise incision on the early cleavage embryos’ zona pellucita prior to their replacement.


Assisted Hatching is applied in patients with poor prognosis such as:

  • couples with advanced maternal age,
  • couples who have encountered repeated failures in vitro fertilisation procedures
  • embryow with abnormal zona pellucida thickness

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